Research progress of interleukin-1 and its receptor antagonist Anakinra in Kawasaki disease
10.3760/cma.j.cn101070-20210226-00234
- VernacularTitle:白细胞介素-1及其受体拮抗剂Anakinra在川崎病中的研究进展
- Author:
Yuanzheng ZHENG
1
;
Jia HOU
;
Yonghao GUI
Author Information
1. 复旦大学附属儿科医院心血管中心，上海 201102
- Keywords:
Kawasaki disease;
Interleukin-1;
Anakinra
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(3):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease (KD) is an acute vasculitis that often occurs in children under 5 years of age, leading to coronary artery aneurysms.It is the leading cause of acquired heart disease in children in many countries.Coronary artery stenosis, thrombosis, and even myocardial infarction may occur in the long-term course of KD, which seriously threaten the health of children.The etiology and pathogenesis of KD are complex, and it is recognized that KD is caused by the interaction of multiple factors like the heredity, immunity, inflammation, and environmental factors.Interleukin-1 plays an important role in the occurrence and progression of KD.This study mainly reviews the research progress of interleukin-1 and its receptor antagonist Anakinra in KD.
