Advances of mechanism of mesenchymal stem cells in animal experiments with bronchial asthma

VernacularTitle:间充质干细胞治疗支气管哮喘的动物实验作用机制研究进展
Author: Mi YAN ¹ ; Tao AI ; Hongjia CHEN ; Lan JIANG
Author Information

1. 电子科技大学医学院附属妇女儿童医院，成都市妇女儿童中心医院儿童呼吸科，成都　610017
Keywords: Mesenchymal stem cell; Bronchial asthma; Immunoregulation; Child
From: Chinese Journal of Applied Clinical Pediatrics 2022;37(2):150-152
CountryChina
Language:Chinese
Abstract: Bronchial asthma is a common chronic airway inflammatory disease in children characterized by hyper-responsiveness, airway inflammation, and airway remodeling caused by immune responses.Currently, some limitations of glucocorticoid and allergen-specific immunotherapy restrict their application to asthma treatment.Based on the results of many animal experiments, mesenchymal stem cells (MSCs) are validated to reduce airway inflammation, improve airway hyper-responsiveness, and reverse airway remodeling through immunomodulation.Therefore, it has great application prospects as an effective therapeutic strategy for children with asthma.To explore the value of MSCs in the treatment of asthma, its underlying mechanisms are reviewed in the present study.