Cornelia de Lange syndrome with recurrent seizures and SMC1A gene c. 2923C > T mutation: a case report and literature review
10.3760/cma.j.cn101070-20200622-01042
- VernacularTitle:SMC1A基因c.2923C>T突变致反复癫痫发作的德朗热综合征1例并文献复习
- Author:
Fangmin ZHANG
1
;
Ziming HAN
;
Xiaoyue WANG
;
Dean ZHAO
;
Meigui HAN
;
Qian HUANG
;
Xiaojuan ZHU
;
Peipei LIU
;
Lingchao WANG
Author Information
1. 新乡医学院第一附属医院儿科，卫辉 453100
- Keywords:
Cornelia de Lange syndrome;
Seizures;
SMC1A gene mutation
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(2):143-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics, clinical manifestations and gene mutation types of Cornelia de Lange syndrome (CdLs), and to improve the understanding of the disease.Methods:Clinical data and gene test results of a pediatric case of CdLs diagnosed in the First Affiliated Hospital of Xinxiang Medical University in August 2019 were analyzed retrospectively.Results:A female patient with 2 years and 8 months old presented a special appearance with a low and flat nose, a wide eye distance, audition ears, a downward inclination of the mouth corner, a high arch of the jaw and a small jaw deformity, who had recurrent seizures, speech and mental retardation.The result of gene test showed the mutation of SMC1A gene c. 2923C > T, and thus the patient was diagnosed as type 2 CdLs. Conclusions:CdLs is a rare genetic metabolic disease with special facial features and physical signs.There is only one case of CdLs with gene mutation of SMC1A in China through literature review.The mutation of SMC1A gene c. 2923C>T in CdLs cases has not been reported at home and abroad, which expands the variation spectrum of the SMC1A gene.
