Case report of anaplastic lymphoma kinase positive histiocytosis in children

VernacularTitle:儿童间变性淋巴瘤激酶阳性的组织细胞增生症1例
Author: Ting ZHANG ¹ ; Ming LI ; Bailing ZHOU ; Yue CHEN ; Yu LYU ; Xin LI
Author Information

1. 昆明市儿童医院呼吸科，昆明　650228
Keywords: Histocytosis; Anaplastic lymphoma kinase; Child
From: Chinese Journal of Applied Clinical Pediatrics 2022;37(1):61-63
CountryChina
Language:Chinese
Abstract: The clinical data of a child with anaplastic lymphoma kinase positive histiocytosis (ALK+ H) diagnosed in April 2020 by Kunming Children′s Hospital were retrospectively analyzed.The male child was 4 months and 29 days old and had multiple nodules throughout the body since 1 week after birth.Skin sarcoidosis examination showed non-Langerhans cell histiocytosis, and immunohistochemistry showed ALK (+ ), CD1a (-), and CD 163(+ ). Therefore, this patient was diagnosed as ALK+ H, which was very rare in clinical practice.Previously reported cases mainly showed soft tissue nodules or thrombocytopenia with anemia.In addition to multiple nodules throughout the body, this patient also had elevated platelets, neutropenia, and abnormal liver function, which was different from previous reports.Hence, this case could be used as a supplement to the disease database.