Clinical feature analysis of medulloblastoma with extraneural metastasis in children
10.3760/cma.j.cn101070-20200826-01410
- VernacularTitle:儿童髓母细胞瘤神经轴外转移的临床特点分析
- Author:
Yan LIU
1
;
Shuxu DU
;
Yanling SUN
;
Xiaojun GONG
;
Miao LI
;
Jin ZHANG
;
Shuting LI
;
Siqi REN
;
Yuan WANG
;
Wanshui WU
;
Liming SUN
Author Information
1. 首都医科大学附属北京世纪坛医院儿科，北京 100038
- Keywords:
Child;
Medulloblastoma;
Extraneural metastasis
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Summarizing the clinical characteristics of extraneural metastasis in childhood medulloblastoma.Methods:A total of 616 cases with medulloblastoma treated in Beijing Shijitan Hospital from April 2010 to April 2019 were analyzed retrospectively, among which 11 cases developed extraneural metastasis.The age of onset, location and time of extraneural metastasis, pathological and molecular typing, treatment and prognosis were descriptively analyzed.The differences of blood biochemical indexes between medulloblastoma cases with and without extraneural metastasis were statistically analyzed by t test. Results:As of February 2020, the median follow-up period was 16 months (ranging from 3 to 69 months). Eleven cases, including 8 males and 3 females, were diagnosed with extraneural metastasis, with the incidence being about 1.8%.The median age of medulloblastoma was 6 years (2-10 years), and the median age at presentation of extraneural metastasis was 7 years (2-12 years). Extraneural metastasis occurred from 0.5 months to 38.0 months after the operation, and the affected location includes bone (6 cases), bone marrow (3 cases), lung (3 cases), pelvis (2 cases) and abdominal cavity (1 case). In these patients, the range of lactic dehydrogenase (LDH) was (2 298.00±1 570.70) U/L and neuron-specific enolase (NSE) was (201.00±68.34) μg/L, which were significantly higher than those in patients without extraneural metastasis [(249.50±46.28) U/L and (22.80±7.12) μg/L, all P<0.05]. Partial patients were treated with chemotherapy, while the majority of them were treated with palliative treatment in the terminal stage, with the survival period mostly less than 10 months. Conclusions:Although there is a low incidence of extraneural metastasis in medulloblastoma pediatric patients, the prognosis of these patients with extraneural metastasis is poor and most of them would die within one year.The most common sites include bone, followed by bone marrow and lungs, which may be related to the spread of cerebrospinal fluid and the increased levels of LDH and NSE.
