Cytokine storms associated with respiratory virus infection and targeted therapy strategies
10.3760/cma.j.cn101070-20210809-00943
- VernacularTitle:呼吸道病毒感染相关细胞因子风暴与靶向治疗策略
- Author:
Ailiang LIU
1
;
Yanmin BAO
;
Yuejie ZHENG
;
Kunling SHEN
Author Information
1. 深圳市儿童医院呼吸科，深圳 518038
- Keywords:
Cytokine storm;
Inflammatory reaction;
Novel coronavirus pneumonia;
Virus characteristics
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(24):1913-1917
- CountryChina
- Language:Chinese
-
Abstract:
Since December 2019, the novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) infection has broken out worldwide, causing enormous social and economic burdens.Sudden exacerbations in SARS-CoV-2 infected people may be caused by infection-related cytokine storms.The basic state of the body and the strength of the immune response determine the prognosis of SARS-CoV-2.The interaction between proinflammatory factors and anti-inflammatory factors, and continued proinflammatory response cause lung edema, exudation, progression to acute respiratory distress syndrome involving the lung tissues and organs, multi-organ failure, and even death.The efficacy of antiviral therapy alone for immune complications like cytokine storm during viral infection is not ideal, and the targeted therapy of cytokines has become a potentially popular therapeutic strategy.Early identification and appropriate treatment of immune complications contribute to reduce the morbidity and mortality of severe viral infections.
