Study on the clinical epidemiological characteristics of human rhinovirus infection in children with community-acquired pneumonia
10.3760/cma.j.cn101070-20210716-00832
- VernacularTitle:儿童社区获得性肺炎中人鼻病毒感染的临床流行病学特征研究
- Author:
Junhong AI
1
;
Gen LU
;
Yun SUN
;
Changchong LI
;
Rong JIN
;
Yunxiao SHANG
;
Baoping XU
;
Zhengde XIE
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院，北京市儿科研究所，感染与病毒研究室，儿科重大疾病研究教育部重点实验室，儿童呼吸道感染性疾病研究北京市重点实验室，中国医学科学院儿童危重症感染诊治创新单元，北京 100045
- Keywords:
Human rhinovirus;
Epidemiology;
Genotype;
Community-acquired pneumonia;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2021;36(24):1866-1870
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the dominant genotypes and epidemic characteristics of human rhinovirus (HRV) in pediatric community-acquired pneumonia (CAP) in China.Methods:Between June 2017 to December 2019, throat swabs or nasopharyngeal aspirates were collected from pediatric CAP patients hospitalized in 6 medical institutions in Southern and Northern China (bounded by Qinling and Huaihe River), respectively.A total of 16 species of common respiratory viruses were screened using respiratory pathogen detection kits.Samples with positive HRV were genotyped for further epidemiological analysis.Results:The total detection rate of HRV in pediatric CAP (2 913 cases) was 12.2%(356 cases) in this study, which was 10.3%(145/1 410 cases) and 14.0%(211/1 503 cases) in Northern and Southern China, respectively.The detection rate of HRV in the Southern region was significantly higher than that in the Northern region, the difference was statistically significant( χ2=9.562, P=0.002). Epidemiological analysis showed that the distribution of HRV-positive cases in the Northern region was similar in all age groups, while 90.5% of positive cases in the Southern region were infants under 3 years.Classified by seasonal distribution, HRV-positive cases in the Northern region were mainly distributed in summer and autumn, while those in the Southern region were mainly distributed in spring and autumn.The coinfection rate of HRV and other pathogens was 40.7%, which was significantly higher in the Southern region than that of Northern region (49.0% vs.28.0%), the difference was statistically significant( χ2=15.801, P<0.001). The most common pathogens mixed with HRV were respiratory syncytial virus (RSV), human boca virus (HBOV) and parainfluenza virus type Ⅲ (PIV3) in the Northern region, with the mixed infection rate of 5.0%, 5.0% and 4.0%, respectively, which were RSV, PIV3 and human metapneumovirus (HMPV) in the Southern region, with the mixed infection rate of 9.0%, 7.0% and 6.0%, respectively.The genotyping results showed that all three HRV genotypes were detected.HRV-A (118/220 cases) was the dominant genotype, followed by HRV-C(82/220 cases). Conclusions:The detection rate of HRV in pediatric CAP cases is 12.2% in this study.There are significant differences in age and seasonal distribution of HRV-positive cases in the Southern and Northern regions.Coinfection of HRV and other pathogens is detected.The coinfection rate is significantly higher in the Southern region than that in the Northern region.HRV-A is the dominant genotype, followed by HRV-C.
