Introduction and interpretation of World Health Organization recomended characteristics of monoclonal antibodies for passive immunization against respiratory syncytial virus disease

VernacularTitle:《世界卫生组织推荐用于呼吸道合胞病毒感染被动免疫理想的单克隆抗体的产品特性》文件介绍与解读
Author: Gen LU ¹ ; Kunling SHEN
Author Information

1. 广州医科大学附属广州市妇女儿童医疗中心呼吸科　510623
Keywords: Prevention; Passive immunity; Respiratory syncytial virus; Monoclonal antibody
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(24):1844-1847
CountryChina
Language:Chinese
Abstract: Respiratory syncytial virus (RSV) is the main pathogen of respiratory diseases in infants and young children worldwide, and the incidence of severe RSV infection remains highest in infants.Effective preventive measures are urgently needed to prevent RSV infection.Currently, no vaccine has been approved to prevent RSV infection.In June 2021, World Health Organization (WHO) proposed the Characteristics of Monoclonal Antibodies for Passive Immunization against Respiratory Syncytial Virus Infection which facilitates the development of high-quality, safe, affordable and effective monoclonal antibodies to prevent severe RSV infection and deaths in infants and young children worldwide.This study aims to interpret this document, thus guiding pediatricians understand the ideal characteristics and application of monoclonal antibodies for passive immunity to RSV infection.