Research progress of different tumor-infiltrating lymphocyte subtypes in triple-negative breast cancer

VernacularTitle:不同肿瘤浸润淋巴细胞亚型在三阴性乳腺癌中的研究进展
Author: Huaiyu YANG ¹ ; Lixue XUAN
Author Information

1. 国家癌症中心　国家肿瘤临床医学研究中心　中国医学科学院北京协和医学院肿瘤医院，北京　100021
Keywords: Triple negative breast cancer; Tumor microenvironment; Tumor infiltrating lymphocytes
From: Chinese Journal of Endocrine Surgery 2022;16(2):237-240
CountryChina
Language:Chinese
Abstract: Triple-negative breast cancer is considered to be the most aggressive subtype of breast cancer. Due to its lack of expression of estrogen receptor (ER) , progesterone receptor (PR) and HER-2, there is still a lack of clear prognostic judgments and biomarkers that guide treatment. With the development of tumor immunology, the relationship between tumor immune microenvironment and tumor occurrence and development has gradually gained attention. More and more evidence suggests that the higher the level of tumor-infiltrating lymphocytes (TIL) infiltration in triple-negative breast cancer lesions, the better the prognosis of patients. However, TIL is not a single type of cell, and its different lymphocyte subpopulations have different prognostic effects in patients with triple-negative breast cancer. This article summarizes the relationship between different immune cell subgroups in the tumor immune microenvironment and the prognosis of TNBC patients.