Clinical value of marker genes in the diagnosis of salivary gland mammary secretory carcinoma
10.3760/cma.j.cn.115807-20220214-00036
- VernacularTitle:标志性基因在涎腺乳腺样分泌性癌诊断中的临床价值
- Author:
Xiangang YIN
1
;
Ling CHEN
;
Suying WANG
;
Rong GE
;
Zheng LI
;
Shanshan XU
Author Information
1. 宁波市临床病理诊断中心，宁波 315021
- Keywords:
Salivary gland neoplasms;
Mammary analogue secretary carcinoma of salivary gland;
ETV6-NTRK3 gene fusion
- From:
Chinese Journal of Endocrine Surgery
2022;16(2):180-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of mammary analogue secretary carcinoma of salivary gland (MASC) .Methods:From Jan. 2018 to Jan. 2021, 28 cases of salivary gland MASC were collected in Ningbo Diagnostic Pathology Center, and 10 cases of acinar cell carcinoma and 10 cases of adenoid cystic carcinoma were selected as controls. Immunohistochemical envision method was used to detect the expression of S-100,, DOG-1, CD117, SOX-10, Mammaglobin and Vimentin, and fluorescence in situ hybridization was used to detect the fusion gene of ETV6-NTRK3.Results:The S-100 protein, SOX-10 and Vimentin of MASC of salivary gland were diffusingly positive (28/28) , Mammaglobin (22/28) and CD117 (19/28) were partially positive, and DOG-1 was negative. ETV6-NTRK3 fusion transcription was successfully detected in 26 of 28 salivary gland MASC cases, of which 23 were positive and 3 were negative.Conclusions:Salivary gland MASC is a low-grade malignant epithelium tumor. Comprehensive detection of the expression levels of S-100 protein, SOX-10, DOG-1, Mammaglobin and CD117 is of great value for the diagnosis and differential diagnosis of MASC. FISH detection of ETV6-NTRK3 gene fusion has important reference value for definite diagnosis.
