The prognostic value of platelet-to-lymphocyte ratio in patients with extracorporeal membrane oxygenation
10.3760/cma.j.issn.1671-0282.2021.12.008
- VernacularTitle:早期血小板与淋巴细胞比值在静脉-动脉体外膜肺氧合患者中的预后价值分析
- Author:
Di AN
1
;
Xufeng CHEN
;
Zhongman ZHANG
;
Yi ZHU
;
Yue ZOU
;
Tao DING
Author Information
1. 南京医科大学第一附属医院急诊医学中心，南京 210029
- Keywords:
Platelet-to-lymphocyte ratio;
Extracorporeal membrane oxygenation;
Continuous renal replacement therapy;
Complication;
Mortality;
Prognosis;
Risk factors;
RO
- From:
Chinese Journal of Emergency Medicine
2021;30(12):1454-1458
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the potential role and prognostic value of platelet-to-lymphocyte ratio (PLR) at an early stage in arterial-venous extracorporeal membrane oxygenation (VA -ECMO).Methods:Totally 83 adult patients with VA-ECMO from June 2018 to June 2020 treated at Emergency Department of Jiangsu Provincial Hospital were retrospectively analyzed. Baseline characteristics between survivors ( n=46) and non-survivors ( n=37) were compared. Logistic regression analysis was used to predict the risk factors associated with 28-day mortality in VA-ECMO patients. The cut-off value was calculated by the receiver operating characteristic (ROC) curve. Results:PLR48-h ( OR=1.018,95% CI: 1.001-1.036, P=0.039) and continuous renal replacement therapy (CRRT) ( OR=7.095,95% CI: 1.099-45.799, P=0.039) were relevant risk factors of 28-day mortality in VA-ECMO patients. The cut-off value of PLR48-h was 156.3 [sensitivity: 57.8%, specificity: 86.1%, and area under the curve (AUC): 0.756]. Compared with the high PLR group (>156.3), the incidences of acute kidney injury (AKI) ( P<0.001) and bleeding events ( P=0.013) were significantly higher in the low PLR group (<156.3). Conclusions:The early PLR reduction and CRRT application during VA-ECMO support are related to poor prognosis.
