Research progress on the anti-tumor effect of oridonin
10.3760/cma.j.cn115398-20210511-00102
- VernacularTitle:冬凌草甲素抗肿瘤作用机制研究进展
- Author:
Hongyang WU
1
;
Xiangrong FAN
;
Hang ZHAO
;
Huanfang FAN
Author Information
1. 河北中医学院研究生学院2020级硕士研究生，石家庄 050091
- Keywords:
Oridonin;
Rabdosiae Rubescentis Herba;
Neoplasms;
Cell proliferation;
Apoptosis;
Autophagy;
Review
- From:
International Journal of Traditional Chinese Medicine
2022;44(5):599-601
- CountryChina
- Language:Chinese
-
Abstract:
Oridonin is one of the main anti-tumor active ingredients of Rabdosiae Rubescentis Herba. In the development process of a variety of malignant tumors, such as liver cancer, breast cancer, cervical cancer, pancreatic cancer, lung cancer, gastric cancer, esophageal cancer, colon cancer, etc, it has a significant inhibitory effect. Oridonin plays the rold of anti-tumor effect mainly by inhibiting tumor cell proliferation, inducing tumor cell apoptosis, inhibiting tumor cell invasion and migration, inducing tumor cell autophagy, reducing telomerase activity and reversing the drug resistance of the tumor cell.
