Correlations between genomic and transcriptome characteristics and immune in hepatocellular carcinoma
10.3760/cma.j.cn371439-20220221-00056
- VernacularTitle:肝细胞癌基因组及转录组特征与免疫相关性
- Author:
Xiaoke SUN
1
;
Yu YANG
Author Information
1. 哈尔滨医科大学附属第二医院肿瘤内科，哈尔滨 150000
- Keywords:
Carcinoma, hepatocellular;
Liver cirrhosis;
Immunotherapy
- From:
Journal of International Oncology
2022;49(5):302-306
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma is a common malignant tumor in China, and its global incidence continues to rise and the mortality rate is high. Aberrations in the liver genome lead to malignant transformation of cells and the development of hepatocellular carcinoma, which are also potential therapeutic targets. Different immune cell components in the hepatocellular carcinoma microenvironment, such as tumor-associated macrophages, neutrophils, can promote tumor progression, and cytotoxic T lymphocytes can destroy tumor cells. Different characteristic gene phenotypes in cells can promote or inhibit immune tolerance, which can explain the potential reasons for the sensitivity or resistance of hepatocellular carcinoma patients to immunotherapy, and provide a reference for the exploration of new immunotherapy targets. Further deepening the understanding of the genomic and transcriptomic features in hepatocellular carcinoma and its correlation with immunotherapy can provide new ideas for clinical diagnosis and treatment.
