Mechanism of drug induced ferroptosis in the treatment of head and neck tumors

VernacularTitle:药物在头颈部肿瘤治疗中引起铁死亡的作用机制
Author: Yan ZENG ¹ ; Pan LUO ; Ziqi WANG ; Weili WU
Author Information

1. 贵州医科大学临床医学院肿瘤学教研室，贵阳　550000
Keywords: Head and neck neoplasms; Ferroptosis; Clinical medicine; Mechanism
From: Journal of International Oncology 2022;49(3):173-176
CountryChina
Language:Chinese
Abstract: Ferroptosis is drived by lipid reactive oxygen species, which plays an important role in the development of tumors. It has been found that a variety of clinical medicines, such as artemisinin derivatives, itraconazole, sulfasala zine, cucurbitacin B, paclitaxel, disulfiram/copper can induce ferroptosis and inhibit tumor growth in head and neck cancer (HNC) through different mechanisms. To study the regulatory mechanism of ferroptosis induced by commonly used drugs in the treatment of HNC can provide reference for the targeted treatment of ferroptosis in HNC.