Research progress on the function and mechanism of FEZF1-AS1 in colon cancer
10.3760/cma.j.issn115396-20220117-00025
- VernacularTitle:FEZF1-AS1在结肠癌中的功能与机制研究进展
- Author:
Xiaoping YANG
1
;
Xueni MA
;
Xiaolu SU
;
Zhiping WU
;
Shangdi ZHANG
;
Tiyun HAN
;
Dekui ZHANG
Author Information
1. 兰州大学第二医院消化科，兰州 730030
- Keywords:
Colonic neoplasms;
Gene expression;
Review;
Long non-coding RNA;
FEZF1- AS1;
Competing endogenous RNA network;
Biological markers
- From:
International Journal of Surgery
2022;49(5):347-351
- CountryChina
- Language:Chinese
-
Abstract:
Colon cancer is a common malignant tumor in the world, however, its pathogenesis still needs further research. FEZF1- AS1 is highly expressed in colon cancer and other malignant tumors, and is associated with clinicopathological features and prognosis of colon cancer patients. In addition, FEZF1- AS1 promotes the proliferation, invasion and migration of colon cancer cells, regulates the cell cycle and inhibits apoptosis through various mechanisms, suggesting that FEZF1- AS1 may be a new important molecular biomarker and a potential therapeutic target for colon cancer. This article reviews the advances in the study of function and mechanism of FEZF1- AS1 in colon cancer.
