Progress of miR-196 in the development and diagnosis of non-small cell lung cancer
10.3760/cma.j.cn115396-20211026-00416
- VernacularTitle:miR-196在非小细胞肺癌发生、发展及诊断中的研究进展
- Author:
Bin WU
1
;
Min ZHENG
;
Ye XU
;
Qingkui GUO
;
Wenliang QIAN
;
Chen ZHU
;
Ning WANG
;
Wen ZHAO
Author Information
1. 上海交通大学医学院附属同仁医院，上海 200336
- Keywords:
Lung neoplasms;
Carcinoma, Non-small-cell lung;
Diagnosis;
miR-196;
Development
- From:
International Journal of Surgery
2022;49(4):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Microribonucleic acid (miRNAs) is a widely existing endogenous single-stranded non-coding small RNA, which is stably expressed in tissues and body fluids. By complementing messenger RNA(mRNA) sequences, miRNAs degrade target mRNA and block the expression of protein-coding genes, playing a key role in post-transcriptional regulation and different biological processes. In recent years, more and more studies have shown that miRNAs are closely related to the occurrence and development of tumors. Among them, as a member of the miRNAs family, microribonucleic acid-196 (miR-196) is abnormally expressed in the serum, tissues and cells of patients with non-small cell lung cancer, participating in the occurrence and development of non-small cell lung cancer and playing an important regulatory role in various biological processes such as proliferation, invasion and metastasis, providing diagnostic evidence for early screening of non-small cell lung cancer.This paper reviews the progress of miR-196 in the development and diagnosis of non-small cell lung cancer.
