A Case of Non-nasal T/NK-cell Lymphoma Occurring in A Patient with Autiphospholipid Syndrome.
- Author:
Jae Wang KIM
;
Sang Seok KIM
;
Kwang Joong KIM
;
Jong Min KIM
;
Chong Ju LEE
;
Hyeong Kik SHIN
- Publication Type:Case Report
- Keywords:
Non-nasal T/NK-cell lymphoma;
Antiphospholipid syndrome
- MeSH:
Adult;
Antibodies, Antiphospholipid;
Antiphospholipid Syndrome;
Female;
Genes, T-Cell Receptor;
Humans;
Lymphoma*;
Lymphoma, T-Cell;
Nasal Cavity;
Skin;
T-Lymphocytes;
Thrombocytopenia
- From:Korean Journal of Dermatology
1999;37(2):229-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Non-nasal T/NK-cell lymphoma(TNKCL) without nasal cavity invasion is a subtype of angiocentric T-cell lymphomas showing the biphenotype of the T-cell and NK-cell. This tumor is characterized by the absence of clonal rearrangement of the T-cell receptor gene, frequent association with Epstein- Barr virus(EBV), poor clinical course, and common extranodal invasion. Antiphospholipid syndrome (APS) is characterized by repetitive spontaneaus abortion, thrombocytopenia, thrombotic symptoms and the positivity to the antiphospholipid antibody. Our patient was a 35-year-old woman with skin lesion on her face. Previously, she had been diagnosed of APS. Histopathological, immunohistochemical and serologic studies could disclose EBV-associated non-nasal TNKCL.
