Expression of PLEK2 in malignant tumors and its influence on invasion and metastasis
10.3760/cma.j.issn115396-20211222-00473
- VernacularTitle:PLEK2在恶性肿瘤中的表达及其对侵袭转移的影响
- Author:
Yongjie JIANG
1
;
Bangguo KOU
;
Pan BIAN
;
Bingtai LI
;
Lanning YIN
Author Information
1. 兰州大学第二医院普外科，兰州 730030
- Keywords:
Carcinoma;
Review;
Prognosis;
PLEK2;
Biomarkers
- From:
International Journal of Surgery
2022;49(2):122-127
- CountryChina
- Language:Chinese
-
Abstract:
PLEK2 (Pleckstrin-2) is a subtype of platelets and leukocytes Pleckstrin, located at 14q23.3-q24.1. Its encoded protein contains 353 amino acids. It plays a role in a variety of cells other than immune cells. The research is relatively limited, mainly involved in the reorganization of cytoskeleton proteins and the regulation of cell extension and migration. PLEK2 plays an important role in the occurrence, development and metastasis of a variety of tumors, and can participate in the regulation of a variety of signal pathways, thereby regulating tumor cell proliferation, invasion and metastasis. PLEK2 is up-regulated in a variety of tumors and has carcinogenic properties. This article reviews the regulatory role of PLEK2 in tumorigenesis, development and metastasis and its impact on tumor prognosis.
