Research progress of regulation relationship between aerobic glycolysis and Wnt/β-catenin pathway in breast cancer
10.3760/cma.j.cn115396-20210917-00369
- VernacularTitle:乳腺癌中有氧糖酵解与Wnt/β-catenin通路调控关系的研究进展
- Author:
Chenxiao LIU
1
;
Deyuan FU
Author Information
1. 大连医科大学临床医学院 116044
- Keywords:
Breast neoplasm;
Glycolysis;
Wnt signaling pathways;
Beta-catenin
- From:
International Journal of Surgery
2021;48(12):861-864
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer as one of the common malignant tumors in women, has received widespread attention. Aerobic glycolysis is the main metabolic pathway of breast cancer cells, and its key enzymes play an important role in the metabolism of cancer cells. The key enzymes of glycolysis are regulated by the Wnt/β-catenin signaling pathway. Abnormal activation of the Wnt/β-catenin signaling pathway regulates downstream target genes, thereby affecting the activities of key glycolysis enzymes. Glycolysis and Wnt/β-catenin signaling pathway play an important role in the occurrence and development of breast cancer, but the specific regulatory relationship between the two has not been studied in depth. Therefore, this article summarizes the regulation relationship between aerobic glycolysis and Wnt/β-catenin pathway in order to explore new strategies for breast cancer treatment.
