Expression of MCM4/PCNA in gastric cancer and its potential as a potential biomarker
10.3760/cma.j.cn121382-20210620-00603
- VernacularTitle:MCM4/PCNA在胃癌组织中的表达及作为潜在生物标志物的可能性研究
- Author:
Xiaolong LI
1
;
Rui SONG
;
Si LI
;
Xiaoning LI
;
Lanshuan GUO
Author Information
1. 保定市第一中心医院普通外一科 071000
- Keywords:
Gastric cancer;
Minichromosome maintenance protein 4;
Proliferating cell nuclear antigen;
Biomarker
- From:
International Journal of Biomedical Engineering
2021;44(6):436-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expressions of minichromosome maintenance protein 4(MCM4) and proliferating cell nuclear antigen (PCNA) in gastric cancer tissues, to explore the relationship between MCM4/PCNA and gastric cancer, and to investigate the possibility of MCM4/PCNA as a potential biomarker for gastric cancer.Methods:Bioinformatics methods were used to analyze the mRNA expressions of MCM4 and PCNA in gastric cancer tissues and adjacent normal tissues. The clinicopathological data of 69 patients with gastric cancer who underwent surgery were retrospectively analyzed. The expression levels of MCM4 and PCNA in gastric cancer tissues and adjacent normal tissues were detected by immunohistochemistry, and their relationship with the clinicopathological characteristics of gastric cancer patients was analyzed.Results:The mRNA levels of MCM4 and PCNA in gastric cancer tissues are significantly higher than those in adjacent normal tissues (all P<0.05). The expression of MCM4 is correlated with the tumor size of gastric cancer ( P=0.037), but there is no significant correlation with gender, age and tumor grade (all P>0.05). Both MCM4 and PCNA proteins are highly expressed in gastric cancer patients. Conclusions:The expression levels of MCM4 and PCNA have a clear correlation with the occurrence of gastric cancer. MCM4 and PCNA are expected to be potential biomarkers for the diagnosis and treatment of gastric cancer.
