Interleukin and perihematomal edema after intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2022.03.011
- VernacularTitle:白细胞介素与脑出血后血肿周围水肿
- Author:
Jinming MA
1
;
Qin LAI
;
Zhiying CHEN
Author Information
1. 九江学院附属医院神经内科，九江 332001
- Keywords:
Cerebral hemorrhage;
Interleukins;
Brain edema;
Blood-brain barrier;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2022;30(3):215-220
- CountryChina
- Language:Chinese
-
Abstract:
In different stages of the course of intracerebral hemorrhage, various interleukins (ILs) play different roles. IL-1α and IL-1β can aggravate perihematomal edema (PHE) by affecting the integrity of the blood-brain barrier in the early stage of intracerebral hemorrhage. IL-6 and IL-8 play a key role in the whole course of intracerebral hemorrhage and affect the severity of PHE by inducing inflammation. IL-3 promotes the development of PHE by promoting microglia activation. IL-11 and IL-17A can be used to assess disease severity and as predictors of PHE, but they do not play a decisive role in the development of intracerebral hemorrhage. IL-4 and IL-10 have certain improvement effects on the development of PHE and the outcomes after cerebral hemorrhage.
