Role of neurovascular units in cerebral small vessel disease
10.3760/cma.j.issn.1673-4165.2022.02.013
- VernacularTitle:神经血管单元在脑小血管病中的作用
- Author:
Yang ZHAO
1
;
Ningde SHU
;
Meiling WANG
;
Qingxin LIU
Author Information
1. 滨州医学院附属医院神经内科，滨州 256600
- Keywords:
Cerebral small vessel diseases;
Neurons;
Neurovascular coupling;
Blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2022;30(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral small vessel disease (CSVD) is a common cerebrovascular disease in clinical practice. Its onset is hidden and its clinical manifestations are diverse. Studies have shown that there are pleiotropic effects and recurrent activation phenomenon between the functional imbalance of neurovascular unit (NVU) and a series of pathophysiological processes, such as vascular endothelial dysfunction, blood-brain barrier permeability change and glial cell activation, which jointly promote the progress of CSVD under the action of inflammatory and immune factors. This article reviews the role of NVU in the occurrence and development of CSVD.
