Neurological deficit and neurobehavioral evaluation of non-human primate ischemic stroke model
10.3760/cma.j.issn.1673-4165.2022.01.013
- VernacularTitle:非人灵长类缺血性卒中模型的神经功能缺损和神经行为学评价
- Author:
Xiaoduo HE
1
;
Di WU
;
Longfei WU
;
Jian CHEN
;
Yuchuan DING
Author Information
1. 首都医科大学宣武医院中美神经科学研究所，北京 100053
- Keywords:
Stroke;
Brain ischemia;
Neurologic examination;
Behavior rating scale;
Disease models, animal;
Primates
- From:
International Journal of Cerebrovascular Diseases
2022;30(1):66-70
- CountryChina
- Language:Chinese
-
Abstract:
Because the clinical studies of neuroprotective drugs ended in failure, the Stroke Treatment Academy Industry Roundtable recommended the use of non-human primates for preclinical research on stroke. Non-human primates are the bridge between basic experiment and clinical research, and the experimental results are of great reference value. However, non-human primate stroke models have a variety of neurological deficits and behavioral evaluation methods, and the scoring methods also have their own emphases. It is easy to have differences in the evaluation, or there are deficiencies in the scale itself, resulting in inaccurate scoring, which directly affects the experimental results and the implementation of subsequent research. This article summarizes the neurological deficits and behavioral evaluation methods of non-human primate stroke model.
