Estrogen and white matter hyperintensities
10.3760/cma.j.issn.1673-4165.2021.12.013
- VernacularTitle:雌激素与脑白质高信号
- Author:
Xiaoying SHI
1
;
Hongzhen HE
;
Xing GUO
;
Xiaoxiao FENG
;
Jinye ZHAO
;
Peiyuan LYU
Author Information
1. 河北医科大学研究生学院，石家庄 050017
- Keywords:
Estrogens;
Hormone replacement therapy;
Cerebral small vessel diseases;
White matter;
Magnetic resonance imaging;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2021;29(12):943-947
- CountryChina
- Language:Chinese
-
Abstract:
Estrogen is an important hormone secreted by the female reproductive system. Its main function is associated with reproduction, growth and development. Studies have shown that estrogen has biological functions such as regulating vasoconstriction, antioxidant stress, anti-inflammatory and neuroprotection, and also affects brain structure and network. Studies have shown that estrogen is closely associated with the occurrence and development of white matter hyperintensities (WMHs). This article reviews the relationship between estrogen and menopausal hormone replacement therapy and WMHs, and their possible pathophysiological mechanisms.
