Apolipoprotein E genotypes and vascular cognitive impairment
10.3760/cma.j.issn.1673-4165.2021.11.010
- VernacularTitle:载脂蛋白E基因型与血管性认知损害
- Author:
Xin ZHAO
1
;
Xinyu ZHANG
;
Yujiao SUN
;
Yanhong DONG
Author Information
1. 华北理工大学研究生院，唐山 063210
- Keywords:
Apolipoproteins E;
Genotype;
Cognition disorders;
Cognition;
Cerebrovascular disorders;
Dementia, vascular;
Genetic predisposition to disease
- From:
International Journal of Cerebrovascular Diseases
2021;29(11):855-858
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment is the only cognitive impairment disease that can be intervened at present. In recent years, the research on its genetic factors has attracted much attention. Among them, apolipoprotein E (ApoE) and its genotypes are closely associated with lipid metabolism, β-amyloid aggregation and deposition, the changes of brain structure and function, and are closely correlated with the pathogenesis of dementia. This article discusses some possible mechanisms of ApoE and its genotypes affecting cognitive function, in order to provide reference for the management of cognitive function in patients with vascular cognitive impairment.
