Role of microglia in vascular cognitive impairment
10.3760/cma.j.issn.1673-4165.2021.11.009
- VernacularTitle:小胶质细胞在血管性认知损害中的作用
- Author:
Yanmei JI
1
;
Wenjun LI
;
Yunhong YANG
;
Lang FANG
;
Jianyang LI
;
Haitao TIAN
;
Yuan SUN
;
Xingfang JIN
Author Information
1. 昆明医科大学附属延安医院老年病科 650051
- Keywords:
Cognition disorders;
Cerebrovascular disorders;
Dementia, vascular;
Microglia;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2021;29(11):850-854
- CountryChina
- Language:Chinese
-
Abstract:
Vascular cognitive impairment (VCI) is a clinical syndrome with impairment of at least one cognitive domain caused by vascular risk factors or cerebrovascular diseases, and its pathogenesis is not completely clear so far. Microglia are innate immune cells in the brain. They participate in many processes such as neuroinflammation, synaptic pruning, myelin regeneration, neurogenesis and connection. They are associated with the occurrence and development of various neurological diseases such as cerebral infarction, Alzheimer's disease, Parkinson's disease, and autism. Recent studies have shown that microglia play an important role in the development of VCI. This article reviews the role of microglia in VCI.
