Correlation between gut microbiota, short-chain fatty acids metabolic disorder and outcomes of patients with hypertensive intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2021.11.007
- VernacularTitle:肠道菌群和短链脂肪酸代谢紊乱与高血压性脑出血患者转归的相关性
- Author:
Chuhong TAN
1
;
Mingsi ZHANG
;
Mengjia YANG
;
Jianhai LIANG
;
Yongming WU
;
Jia YIN
;
Qiheng WU
Author Information
1. 南方医科大学南方医院重症医学科，广州 510515
- Keywords:
Cerebral hemorrhage;
Gastrointestinal microbiome;
Fatty acids, volatile;
Dysbiosis;
Treatment outcome
- From:
International Journal of Cerebrovascular Diseases
2021;29(11):837-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the metabolic disorder of gut microbiota and short-chain fatty acids (SCFAs) in patients with hypertensive intracerebral hemorrhage and their correlations with the poor outcomes.Methods:Thirty-eight patients with hypertensive intracerebral hemorrhage within 7 d of onset and 32 healthy controls were enrolled prospectively. Fecal samples were collected for 16S rRNA sequencing and SCFAs levels detection. The outcome was evaluated by the modified Rankin Scale at 90 d after the onset, and >2 points were defined as a poor outcome. Multivariate logistic regression model was used to determine the correlations between the gut microbiota and the fecal SCFAs levels and outcomes. Results:The gut microbiota of patients with hypertensive intracerebral hemorrhage was significantly different from that of healthy control group. It is manifested as a decrease in α diversity, a difference in β diversity, an increase in the abundance of potential undesirable bacteria, a decrease in the abundance of common SCFA-producing bacteria and a decrease in the fecal SCFAs levels. In patients with hypertensive intracerebral hemorrhage, compared with the good outcome group, the α diversity of the gut microbiota, the abundance of SCFA-producing bacteria such as Lacetospirillum and Bacteroides, and the total SCFAs, acetic acid and propionic acid levels decreased in the poor outcome group. Multivariate logistic regression analysis showed that after adjusting for potential confounding factors, the decrease of fecal SCFAs levels after log2 conversion was significantly and independently correlated with the poor outcomes. Conclusion:Patients with hypertensive intracerebral hemorrhage have gut microbiota and SCFAs metabolic disorder, the latter is significantly correlated with the poor outcomes. Gut microbiota and SCFAs may become an outcome marker and treatment target for patients with hypertensive intracerebral hemorrhage
