Correlation between diabetic peripheral neuropathy and overall burden of cerebral small vessel disease in patients with type 2 diabetes
10.3760/cma.j.issn.1673-4165.2021.11.006
- VernacularTitle:糖尿病周围神经病变与2型糖尿病患者脑小血管病总体负担的相关性
- Author:
Yingqi JIANG
1
;
Yue TAN
Author Information
1. 昆明医科大学第二附属医院脑血管病科，昆明 650101
- Keywords:
Cerebral small vessel diseases;
Peripheral nervous system diseases;
Diabetes mellitus, type 2;
Magnetic resonance imaging
- From:
International Journal of Cerebrovascular Diseases
2021;29(11):830-836
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between diabetic peripheral neuropathy (DPN) and the overall burden of cerebral small vessel disease (CSVD) in patients with type 2 diabetes.Methods:Patients with type 2 diabetes and CSVD admitted to the Departments of Neurology and Departments of Cerebrovascular Diseases of the Second Affiliated Hospital of Kunming Medical University from June 2018 to July 2021 were enrolled retrospectively. An electromyography evoked potential meter was used to detect peripheral nerves and record the nerve conduction velocity, including median nerve, ulnar nerve, posterior tibial nerve, common peroneal nerve, and sural nerve. MRI examination and CSVD overall burden score were performed on all patients. Ordinal logistic regression analysis was used to determine the independent correlation between DPN and nerve conduction velocity and the overall burden of CSVD. Results:A total of 142 patients were enrolled. Their age was 67.22±8.42 years; 65 were males (45.8%). The overall burden of CSVD: 69 patients were in 0-point group (48.6%), 32 were in 1-point group (22.5%), 19 were in 2-point group (13.4%), 12 were in 3-point group (8.5%), and 10 were in 4-point group (7%). Univariate analysis showed that there were significant differences in age, hypertension, DPN, median nerve motor conduction velocity (MCV), ulnar nerve MCV, common peroneal nerve MCV, median nerve sensory conduction velocity (SCV), ulnar nerve SCV, posterior tibial nerve SCV, common peroneal nerve SCV and sural nerve SCV among the different CSVD overall burden score groups (all P<0.05). Ordinal multi-classification logistic regression analysis showed that age (odds ratio [ OR] 1.051, 95% confidence interval [ CI]1.000-1.104; P=0.048), DPN ( OR 2.446, 95% CI 1.050-5.697; P=0.038), hypertension ( OR 3.578, 95% CI 1.627-7.867; P=0.002) were independently positively correlated with the overall burden of CSVD; common peroneal nerve SCV ( OR 0.972, 95% CI 0.946-0.998; P=0.035) and sural nerve SCV ( OR 0.940, 95% CI 0.917-0.964; P<0.001) were independently negatively correlated with the overall burden of CSVD. Conclusion:DPN is positively correlated with the overall burden of CSVD. Common peroneal nerve and sural nerve SCV are negatively correlated with the overall burden of CSVD.
