Extrapulmonary manifestations and pathogenesis of adenovirus infection in children
10.3760/cma.j.issn.1673-4408.2022.04.007
- VernacularTitle:儿童腺病毒感染的肺外表现及发病机制
- Author:
Ronghua ZHOU
1
;
Xuehua XU
;
Gen LU
Author Information
1. 广州医科大学附属妇女儿童医疗中心呼吸科 510120
- Keywords:
Children;
Human adenovirus;
Extrapulmonary manifestations;
Pathogenesis
- From:
International Journal of Pediatrics
2022;49(4):245-248
- CountryChina
- Language:Chinese
-
Abstract:
Human adenovirus(HAdV)is a double-stranded DNA virus with multiple serotypes.Owing to their genetic heterogeneity, HAdVs display broad tissue tropism and can infect several organs or tissues.Besides the most common respiratory system, different types of HAdV can enter into multi-tissue and cells of the whole body through different receptors and mechanisms, directly destroy the host cells and also trigger immune response that course further damages.Then a variety of extrapulmonary manifestations would appear, such as gastroenteritis, encephalitis, myocarditis, hemorrhagic cystitis, hemophagocytosis and conjunctivitis, which seriously threaten the health of children.
