Immunological effects of type I interferon in systemic lupus erythematosus
10.3760/cma.j.issn.1673-4408.2022.02.013
- VernacularTitle:Ⅰ型干扰素在系统性红斑狼疮中的免疫学效应
- Author:
Yuanyan JIANG
1
;
Li SUN
;
Hong XU
Author Information
1. 复旦大学附属儿科医院风湿科，上海 201102
- Keywords:
Type Ⅰ interferon;
Systemic lupus erythematosus
- From:
International Journal of Pediatrics
2022;49(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus(SLE) is an autoimmune disease with diverse clinical manifestations, and the mechanism of its immune disorder has not been fully defined.Previous studies have shown that type I interferon plays an important role in SLE.Type I interferon is mainly produced by macrophages and dendritic cells, and the interferon-stimulated genes in various immune cells of SLE children were significantly increased.Researchers have found that in addition to interacting with neutrophil extracellular traps, IFN-α can regulate the function of B cells, maintain and amplify autoantibodies, affect the balance of T cell subsets, ultimately aggravate autoimmune abnormalities in SLE patients.Here we review the immunological effects of type I interferon in SLE patients.
