Research model of nonalcoholic fatty liver disease in children
10.3760/cma.j.issn.1673-4408.2022.02.011
- VernacularTitle:儿童非酒精性脂肪肝病研究模型
- Author:
Zhaoyuan WU
1
;
Jingqiang WANG
;
Junfen FU
Author Information
1. 浙江大学医学院，杭州 310030
- Keywords:
Nonalcoholic fatty liver disease;
Children;
Research model
- From:
International Journal of Pediatrics
2022;49(2):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease(NAFLD)has become one of the great risks for children′s development and health, while its pathogenesis and progression characteristics are still not clear.The establishment of NAFLD specific research model can help to explore and reveal the role of related pathways in the occurrence and development of NAFLD.The existing models for the study of NAFLD in children mainly include diet-induced animal models and in vitro hepatocyte culture models.In recent years, organoids cultured from stem cells have similar spatial tissues of corresponding organs and can reproduce some functions of corresponding organs, which can be used to simulate liver inflammation and fibrosis process.In this paper, we will introduce these models and methods, focus on the construction and application of organoids, and look forward to the application of models for children NAFLD in the future.
