Relationship between microRNA-208 and the pathogenesis of coronary artery lesion in Kawasaki disease
10.3760/cma.j.issn.1673-4408.2022.02.004
- VernacularTitle:MicroRNA-208与川崎病冠状动脉损伤发病机制关系研究进展
- Author:
Xiangtong ZHANG
1
;
Mingguo XU
Author Information
1. 汕头大学医学院 515000
- Keywords:
Kawasaki disease;
Coronary artery lesion;
MicroRNA;
MicroRNA-208
- From:
International Journal of Pediatrics
2022;49(2):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Kawasaki disease(KD) is a febrile vasculitis in childhood.It has become the most prominent cause of pediatric secondary cardiovascular disease as it is associated with coronary artery lesion(CAL). Even though intravenous immunoglobulin treatment has greatly lowered the incidence of coronary artery aneurysm, the existence of IVIG-resistant KD indicates a part of patients are still at a high risk of CAL, which brings them a huge psychiatric and financial burden.Therefore, studying the pathogenesis of CAL associated with KD is of great significance.This article reviews the related mechanism of KD and the associated CAL.Meanwhile, it illustrates the connection between microRNA-208 and CAL, on which basis the perspective of microRNA-208 possibly involving in the KD-associated CAL is given.
