Advance in role of cilia in the pathogenesis of congenital heart disease
10.3760/cma.j.issn.1673-4408.2022.02.002
- VernacularTitle:纤毛在先天性心脏病发病中的作用和机制研究进展
- Author:
Quannan ZHUANG
1
;
Wei SHENG
;
Guoying HUANG
Author Information
1. 复旦大学附属儿科医院儿科研究所 上海市出生缺陷防治重点实验室 201102
- Keywords:
Cilia;
Congenital heart disease;
Primary ciliary dyskinesia;
Signaling pathway
- From:
International Journal of Pediatrics
2022;49(2):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease(CHD)is one of the most common genetic diseases, mainly refers to the abnormal cardiovascular development caused by various abnormal factors during fetal development.Studies have found that the normal development of cardiovascular functional structure requires accurate positioning of the left-right asymmetry.As an essential link in body material metabolism and signal-transducing mechanism, cilia may participate in the pathogenesis of CHD by affecting the distribution of the left-right asymmetry of human organs and tissues during embryonic development.Therefore, a thorough understanding of the role, molecular mechanism, and related regulatory genes of cilia in CHD can provide accurate diagnosis and treatment for clinical work to obtain a better prognosis.Here we review the effects of cilia on the positioning of the left-right asymmetry during embryo development and its role in the pathogenesis of CHD.
