The role and significance of matrix metalloproteinase-7 in hepatobiliary diseases
10.3760/cma.j.issn.1673-4408.2022.01.011
- VernacularTitle:基质金属蛋白酶-7在肝胆疾病中的作用与意义
- Author:
Yuhong LI
1
;
Lingfen XU
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Keywords:
Matrix metalloproteinase-7;
Hepatobiliary diseases;
Biliary atresia
- From:
International Journal of Pediatrics
2022;49(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases(MMPs)are a large family of zinc-dependent endopeptidases, which are mainly synthesized by connective tissues, it can degrade the extracellular matrix(ECM)and basement membrane, affect the regeneration and reconstruction of normal tissues, and participate in the pathological process of malignant tumors.Matrix metalloproteinase-7(MMP-7)is the smallest member of the metalloproteinase family.It is expressed in many tissues of the body, such as thyroid, breast, lung, digestive tract, reproductive system and hepatobiliary system.In recent years, the expression of MMP-7 in hepatobiliary diseases has attracted more and more attention.MMP-7 is not only involved in the growth, metastasis and invasion process of hepatobiliary malignant tumors, but also highly expressed in liver fibrosis, biliary atresia and other diseases.This paper reviews the expression of MMP-7 in the above diseases.
