Advance in application and efficacy of ketogenic diet therapy in drug-resistant epilepsy caused by gene mutation
10.3760/cma.j.issn.1673-4408.2022.01.009
- VernacularTitle:生酮饮食在基因突变所致难治性癫痫中应用及疗效的研究进展
- Author:
Yu FANG
1
;
Jianxiang LIAO
Author Information
1. 中国医科大学深圳市儿童医院神经内科 518038
- Keywords:
Drug-resistant epilepsy;
Gene mutation;
Ketogenic diet;
Application;
Efficacy
- From:
International Journal of Pediatrics
2022;49(1):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Genetic factors are important causes of drug-resistant epilepsy.In most cases, epilepsy caused by gene mutation cannot be controlled by existing antiepileptic drugs.Ketogenic diet controls seizures through multi-target mechanism, which is widely used in the treatment of drug-resistant epilepsy caused by gene mutation.In this paper, the advance in application and efficacy of ketogenic diet therapy in 23 kinds of gene mutation related drug-resistant epilepsy is reviewed, which involves energy metabolism, ion channel, mTOR signaling pathway and some other rare diseases.
