The effect of CYP2C19 genetic polymorphism on proton pump inhibitors and the efficacy of Hp eradication in children
10.3760/cma.j.issn.1673-4408.2022.01.005
- VernacularTitle:CYP2C19基因多态性对质子泵抑制剂代谢及儿童幽门螺杆菌根除疗效的影响
- Author:
Xixi ZHOU
1
;
Zhongyue LI
Author Information
1. 重庆医科大学附属儿童医院消化科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿科学重庆市重点实验室 400014
- Keywords:
Children;
CYP2C19 genetic polymorphism;
Proton pump inhibitors;
Helicobacter pylori
- From:
International Journal of Pediatrics
2022;49(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
The polymorphism of CYP2C19 gene constitutes the basis for the difference in enzyme activity and affects the metabolism of many drugs including proton pump inhibitors.The distribution of CYP2C19 gene varies by region and race.The study on the relationship between CYP2C19 genotype and proton pump inhibitors is of great significance for the individualized treatment of Helicobacter pylori (Hp) in children.This paper reviews the effects of CYP2C19 gene polymorphism on proton pump inhibitors and the efficacy of Hp eradication in children.
