Advances of retinoic acid-inducible gene I in kidney diseases
10.3760/cma.j.issn.1673-4408.2021.12.011
- VernacularTitle:维甲酸诱导基因-I在肾脏疾病中的研究进展
- Author:
Peihua ZHENG
1
;
Jing YU
;
Songming HUANG
Author Information
1. 南京医科大学附属儿童医院肾脏科 210008
- Keywords:
Kidney diseases;
Innate immunity;
Inflammation;
Retinoic acid-inducible gene I
- From:
International Journal of Pediatrics
2021;48(12):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Retinoic acid-inducible gene I is an important intracellular pattern recognition receptor in antiviral innate immune responses.After recognition of viral RNA, retinoic acid-inducible gene I triggers antiviral signaling pathways which induce the production of interferons and proinflammatory cytokines.Kidney is an important organ of human body.The occurrence of kidney diseases in childhood has a great impact on children's growth and daily life.Recent studies have shown that retinoic acid-inducible gene I can participate in inflammation and immune responses of kidney, and promote the occurrence and progression of kidney diseases.This article reviews the research progress of retinoic acid-inducible gene I in kidney diseases, and discusses its application prospect as a biomarker and therapeutic target of kidney diseases.
