Progress on the role of pulmonary macrophages in bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2021.12.007
- VernacularTitle:肺巨噬细胞调控支气管肺发育不良发生的研究进展
- Author:
Yajin WEN
1
;
Xiaobo ZHANG
;
Yuanyuan QI
Author Information
1. 复旦大学附属儿科医院呼吸科，上海 201102
- Keywords:
Premature infant;
Bronchopulmonary dysplasia;
Macrophage
- From:
International Journal of Pediatrics
2021;48(12):823-827
- CountryChina
- Language:Chinese
-
Abstract:
Bronchopulmonary dysplasia(BPD)is one of the most common respiratory diseases in premature infants, and many factors affect the development of premature lung.Recent studies have shown that pulmonary macrophages play an important role in the occurrence of BPD.The number of macrophages in the lung increases in the process of BPD, and classically activated M1 cells dominate, which causes excessive production of pro-inflammatory cytokines such as interleukin-1 and oxidation substances such as reactive oxygen species, promotes the apoptosis of lung cells, and affects the development of alveolar structure and pulmonary microvasculature.Besides, the decrease of autophagy activity of neonatal alveolar macrophages contributes to the occurrence of BPD, but the mechanism is still unclear.This article reviews research progress on the role of pulmonary macrophages in bronchopulmonary dysplasia, in order to further explore the significance of them in diagnosis and treatment of BPD and improve the quality of life of children with BPD.
