Progress on the mechanism of respiratory syncytial virus infection, recurrent wheezing and bronchial asthma in infants
10.3760/cma.j.issn.1673-4408.2021.12.002
- VernacularTitle:婴幼儿呼吸道合胞病毒感染与反复喘息及支气管哮喘相关机制的研究进展
- Author:
Fanghan HE
1
;
Qi CHENG
;
Yunxiao SHANG
Author Information
1. 中国医科大学附属盛京医院小儿呼吸内科，沈阳 110004
- Keywords:
Bronchial asthma;
Respiratory syncytial virus;
Epithelial injury;
Immune disorder
- From:
International Journal of Pediatrics
2021;48(12):799-802
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory syncytial virus(RSV) is a common pathogen of respiratory tract infection in children, and its related lower respiratory tract infection is associated with subsequent repeated wheezing and bronchial asthma, but the specific pathogenesis is still unclear.In recent years, it has been found that respiratory syncytial virus infection leads to the injury of respiratory epithelial cells, the release of inflammatory mediators and the disorder of immune function, which are involved in the pathogenesis of asthma.And the early intervention of viral infection and the development of antiviral drugs will improve the occurrence of recurrent wheezing and asthma to a certain extent.Therefore, this article reviews the relationship between recurrent wheezing and asthma caused by respiratory syncytial virus and the effects of anti-respiratory syncytial virus drugs and vaccines.
