Progress of the correlation of microRNA with diffuse large B-cell lymphoma and its treatment application
10.3760/cma.j.cn115356-20210604-00137
- VernacularTitle:微RNA与弥漫大B细胞淋巴瘤的相关性及其治疗应用研究进展
- Author:
Peng LIU
1
;
Yue XU
;
Yanli WANG
;
Li LI
;
Guitao JIE
Author Information
1. 潍坊医学院临床医学院，潍坊 261000
- Keywords:
Lymphoma, large B-cell, diffuse;
MicroRNAs;
Molecular typing;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2022;31(3):189-192
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) plays an important role in the development of diffuse large B-cell lymphoma (DLBCL) by binding to the 3′ non-coding region of the target gene mRNA to regulate gene expression after transcription. The expression level of miRNA is closely related to the clinical staging, typing, prognosis assessment, and therapeutic effect of DLBCL. miRNA has a great potential as that of DLBCL-related biomarkers, and because of the close link between the two, miRNA-based therapies are expected to lead to new treatment options for DLBCL patients.
