Chronic lymphocytic leukemia with t(14;18)(q32;q21): report of 3 cases and review of literature

VernacularTitle:伴t（14；18）（q32；q21）慢性淋巴细胞白血病3例并文献复习
Author: Jianwei LI ¹ ; Cui MAO ; Jianchun CHEN ; Xiaodong JIA ; Haihuan MA ; Haiyan CHANG ; Liujun HAN ; Xiao TAN
Author Information

1. 天津金域医学检验实验室有限公司细胞遗传室，天津　300392
Keywords: Leukemia, lymphocytes, chronic; t(14; 18)(q32; q21); Trisomy 12; Prognosis; Diagnosis
From: Journal of Leukemia & Lymphoma 2022;31(1):46-50
CountryChina
Language:Chinese
Abstract: Objective:To improve the understanding of chronic lymphoblastic leukemia (CLL) with t(14;18)(q32;q21).Methods:The clinical data of 3 cases diagnosed as CLL with t(14;18)(q32;q21) in the Tianjin KingMed Medical Laboratory from January 2020 to January 2021 were retrospectively analyzed. The clinicopathological data, morphological examination, immunophenotype, cytogenetics and somatic mutation of immunoglobulin heavy chain variable region genes of patients were comprehensively analyzed, and the literature was reviewed.Results:All the 3 patients showed lymphatic proliferative diseases, and their morphological characteristics and immunophenotype were typical characteristics of CLL.Conclusions:The diagnosis of CLL is mainly based on the typical morphology and immunophenotype of tumor cells. The presence of t(14;18) should not be used to exclude the diagnosis of CLL.