Research progress of new drug delivery system of gambogic acid
- VernacularTitle:藤黄酸新型给药系统的研究进展
- Author:
Shaowa LYU
1
;
Fali SU
1
;
Yuyan GUO
1
;
Meng LI
1
;
Yang ZHAO
1
;
Huan ZHANG
1
;
Jianmin LI
1
Author Information
1. College of Pharmacy/Key Lab for Basis and Application Research of Northern Medicine of Ministry of Education，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
gambogic acid;
drug delivery system;
bioavailability;
clinical application
- From:
China Pharmacy
2022;33(13):1660-1664
- CountryChina
- Language:Chinese
-
Abstract:
Gambogic acid is the main active component of Garcinia hanburyi Hook. f. ，which can inhibit the growth of a variety of tumor cells. However ，its low solubility ，short half-life and poor stability limit its clinical application to a certain extent. In order to improve the above shortcomings and improve the bioavailability of gambogic acid ，many studies have used covalent binding and physical encapsulation methods to obtain a new gambogic acid delivery system with targeting ，high permeability ，stability， biocompatibility，in vivo long circulation and other properties ，such as polymer prodrug delivery system ，anoxic prodrug delivery system，magnetic field responsive prodrug delivery system ，multi environment sensitive prodrug delivery system ，bionic nano drug delivery system. This paper reviews the new drug delivery system and its characteristics of gambogic acid. The results show that the design of drug carrier has greatly improved the defects of gambogic acid ，and the introduction of more responsive groups into gambogic acid drug carrier may make it achieve better antitumor effect.
