Co-occurrence of an adenoma malignum and an endocervical-type adenocarcinoma of the uterine cervix in a woman with Peutz-Jeghers syndrome.
10.3802/jgo.2010.21.3.203
- Author:
Yu Jin KOO
1
;
Ji Eun LEE
;
Sung Ran HONG
;
Yong Soon KWON
Author Information
1. Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. kbongchun@hanmail.net
- Publication Type:Case Report
- Keywords:
Peutz-Jeghers syndrome;
Adenoma malignum;
Adenocarcinoma
- MeSH:
Adenocarcinoma;
Adenoma;
Adult;
Biopsy;
Cervix Uteri;
Chemotherapy, Adjuvant;
Female;
Follow-Up Studies;
Gynecological Examination;
Humans;
Hysterectomy;
Lymph Node Excision;
Peutz-Jeghers Syndrome;
Recurrence;
Uterine Hemorrhage
- From:Journal of Gynecologic Oncology
2010;21(3):203-206
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a rare co-occurrence of an adenoma malignum and an adenocarcinoma in a 30-year-old woman with Peutz-Jeghers syndrome. The woman was diagnosed with Peutz-Jeghers syndrome based on an endoscopic biopsy after vaginal bleeding. A pelvic examination and an MRI revealed the co-occurrence of a 4x5 cm protruding adenocarcinoma of FIGO stage Ib2 based on a punch biopsy and a 4.5x5.7 cm multilocular cystic mass above the solid cancer. The patient received two courses of neoadjuvant chemotherapy, followed by a laparoscopic radical hysterectomy with pelvic lymph node dissection. Pathologic findings were consistent with adenocarcinoma (40%) and adenoma malignum (60%) confined to the cervix. Three courses of adjuvant chemotherapy were performed and no clinical evidence of recurrence was seen during a 12 month follow-up period. This study will contribute to defining the best diagnosis and treatment for these rare complicating tumors.
