Analysis of clinical significance and prognostic impact of TET2 single nucleotide polymorphism I1762V in patients with acute myeloid leukemia.
10.3760/cma.j.issn.0253-2727.2022.03.010
- Author:
Yang Wei LI
1
;
Zhen GUO
1
;
Lin Lin WANG
1
;
Ling ZHOU
1
;
Xiao Dong LYU
1
;
Yong Ping SONG
2
Author Information
1. Central Lab, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.
2. Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, China.
- Publication Type:Journal Article
- Keywords:
Gene mutation;
Gene, TET2;
Leukemia, myeloid, acute;
Single nucleotide polymorphism
- MeSH:
DNA-Binding Proteins/genetics*;
Dioxygenases/genetics*;
Humans;
Leukemia, Myeloid, Acute/genetics*;
Mutation;
Nuclear Proteins/genetics*;
Polymorphism, Single Nucleotide;
Prognosis
- From:
Chinese Journal of Hematology
2022;43(3):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective: This study aimed to investigate the clinical and prognostic significance of TET2 single nucleotide polymorphism I1762V in patients with acute myeloid leukemia (AML) . Methods: The high-throughput sequencing method was used to sequence 58 hematological tumor-related genes in bone marrow samples from 413 patients with AML. TET2 I1762V and other somatic mutations were annotated and compared with patients' clinical information and prognosis. Results: I1762V was found in 154 patients with AML, which was significantly different from the general population in NyuWa Chinese Population Variant Database (χ(2)=72.4, P<0.001) . I1762V was not related to sex, age, and karyotype of patients with AML (P>0.05) . Patients with I1762V had a significantly higher proportion of NPM1 and KIT gene mutations than others (P<0.001) . NPM1 and KIT mutations were mutually exclusive. The survival analysis results revealed that the overall survival (OS) and progression-free survival (PFS) of patients with AML with I1762V were significantly greater than those of wild-type patients (HR=0.57, P=0.030; HR=0.55, P=0.020) , whereas the OS and PFS in patients with AML with DNMT3A mutation (with or without I1762V mutation) were lower than those of wild-type patients (HR=1.79, P=0.030; HR=1.74, P=0.040) . Conclusion: TET2 SNP I1762V has been linked to AML. I1762V is a prognostic factor of patients with AML, which can be used to guide the treatment and evaluate the prognosis of AML.
