Review of factors in pterygium pathology
10.3980/j.issn.1672-5123.2022.7.13
- VernacularTitle:翼状胬肉相关致病因子的研究进展
- Author:
Yang CHEN
1
;
Chao-Qun WEI
1
;
Yu MI
1
;
Hong-Yan GE
1
Author Information
1. Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
- Publication Type:Journal Article
- Keywords:
pterygium;
epithelial-mesenchymal cell transition;
vascular endothelial growth factor;
transforming growth factor-beta;
P53
- From:
International Eye Science
2022;22(7):1133-1136
- CountryChina
- Language:Chinese
-
Abstract:
Pterygium is an ocular surface disease formed by many factors and associate with a series of changes caused by ultraviolet irradiation and radiation, its pathogenesis is still uncertain. Elevated vascular endothelial growth factor(VEGF), inflammatory infiltrates, angiogenesis, oxidative stress, epithelial-mesenchymal cell transition(EMT), and tumor suppressor gene inactivation are currently recognized causes of pterygium. The mechanism of this factor in pterygium deveopment is still not completely understood. This review aimed to investigate the role of these factors in pterygium formation and provide targeted therapy and effective preventive measures for clinical diagnosis and treatment.
