Application and research progress of in situ gel for local treatment of periodontitis
10.11665/j.issn.1000-5048.20220315
- VernacularTitle:原位凝胶在牙周炎治疗中的应用及其研究进展
- Author:
Kang SHA
1
;
Jiachen LI
;
Xiaole QI
Author Information
1. 中国药科大学药学院药剂系
- Publication Type:Journal Article
- Keywords:
in situ gel;
periodontitis;
gelling mechanism;
local treatment;
microsphere
- From:
Journal of China Pharmaceutical University
2022;53(3):365-375
- CountryChina
- Language:Chinese
-
Abstract:
Recently, in situ gel has been widely used as a local delivery system for periodontitis treatment because of its lesion injectability, local drug depot function, and drug sustained-release effect.Different therapeutic purposes can be achieved by loading different types of drugs such as antibiotics, bioactive factors, etc.In this review, different types of in situ gel with temperature-sensitive, ion-sensitive, pH-sensitive and solvent-exchanged characteristics were introduced for their applications and limitations in the delivery of drug for periodontitis;and the elimination of periodontal inflammation, periodontal tissue repair and the long-term role after loading microsphere achieved by the in situ gel system were also reviewed.
