Advances in self-assembled peptide hydrogels for bone regeneration
10.11665/j.issn.1000-5048.20220314
- VernacularTitle:自组装多肽骨修复水凝胶的研究进展
- Author:
Liu XU
1
;
Shan XU
;
Tangyong XIANG
;
Zhengzhou SHA
;
Jian ZHANG
;
Zhipeng CHEN
Author Information
1. 南京中医药大学药学院
- Publication Type:Journal Article
- Keywords:
self-assembly;
peptide;
bone reparation;
hydrogel;
biomaterials
- From:
Journal of China Pharmaceutical University
2022;53(3):356-364
- CountryChina
- Language:Chinese
-
Abstract:
The development of osteoinductive bone-filling biomaterials for bone regeneration is of great significance.Self-assembled peptide hydrogels with high biomimetic extracellular matrix structure, low immunogenicity, easy synthesis and modification, and flexible loading capacity provide a highly efficient therapeutic platform for bone tissue repair.Herein, we discuss the design principles of self-assembled peptide hydrogels, report the structural characteristics and assembly mechanisms of self-assembled peptides, and highlight recent advances in self-assembled peptide hydrogels for bone regeneration, including delivery to cells , bone morphogenetic proteins, active factors and small molecular substances.Finally, the bottleneck and development direction of self-assembled peptide hydrogels are pointed out, aiming to provide guidance for the construction of hydrogel delivery systems with high osteogenic properties.
