Progress in lipid emulsions as antidotes to reverse drug poisoning
10.11665/j.issn.1000-5048.20220313
- VernacularTitle:脂肪乳在药物中毒解救中的应用研究
- Author:
Zhi LI
1
;
Meng LI
;
Hao SUN
;
Dongfei LIU
Author Information
1. 中国药科大学药剂学教研室
- Publication Type:Journal Article
- Keywords:
lipid emulsion;
antidote;
drug poisoning;
detoxification mechanism;
lipid sink theory
- From:
Journal of China Pharmaceutical University
2022;53(3):348-355
- CountryChina
- Language:Chinese
-
Abstract:
Due to their good safety, wide application scope and quick onset time, lipid emulsions are full of promise to reverse drug poisoning. In this review, a number of clinical case reports were summarized to analyze the detoxification effect of lipid emulsions on local anesthetic, antiarrhythmic, psychotropic and organophosphate poisoning, as well as the possible adverse reactions of lipid emulsions therapy.Meanwhile, the mechanisms underlying lipid emulsions therapy, such as lipid sink theory, enhanced body basal metabolism and positively affected cardiovascular function, were fully interpreted.Besides, a few potential solutions to the problems still existing in lipid emulsions therapy were proposed, in order to consolidate the understanding of lipid emulsions therapy and promote its rational application in reversing drug poisoning.
