Preparation and characterization of dasatinib albumin micelles

VernacularTitle:达沙替尼白蛋白胶束的制备与表征
Author: Wendie WANG ¹ ; Jiyuan ZHOU ; Lidan TANG ; Tingjie YIN
Author Information

1. 南京医科大学附属常州第二人民医院药学部
Publication Type:Journal Article
Keywords: dasatinib; albumin amphiphilic modification; albumin micelle; preparation; characterization
From: Journal of China Pharmaceutical University 2022;53(3):286-292
CountryChina
Language:Chinese
Abstract: In this study, a polyethylene glycol and dodecaldehyde modified bovine serum albumin (PEG-DSA) was developed, and its feasibility as a new high-efficiency micellar carrier for dasatinib (DAS) was explored.Circular dichroism, 1H NMR, elemental analysis, FT-IR and other methods were used to characterize the material structure and the single factor method was used to optimize the process of PEG-DSA/DAS micelles and non-PEGylated control micelles DSA/DAS.The results indicated that the optimal formulation was obtained with a mass ratio of 4∶1 between PEG-DSA and DAS, with average particle size of (37.21 ± 0.21) nm, polydispersion index (PDI) of (0.24 ± 0.04), Zeta potential of ? (15.68 ± 0.19) mV, drug loading (DL) capacity of (10.22 ± 0.34) %, and encapsulation efficiency (EE) of (42.73 ± 1.15) %. Compared with the currently reported nano-formulations of DAS, the drug loading of PEG-DSA/DAS micellar formulations was significantly increased with potential for further development.