Application of vascularized organ-on-a-chip in simulating physiological and pathological processes
10.11665/j.issn.1000-5048.20220302
- VernacularTitle:血管化器官芯片在模拟生理和病理过程中的应用
- Author:
Hongting LIU
1
;
Xiaoxuan JI
;
Jing LI
;
Minjie SUN
Author Information
1. 中国药科大学药学院药剂系
- Publication Type:Journal Article
- Keywords:
organ-on-a-chip;
vascular system;
angiogenesis and vasculogenesis;
physiological and pathological model
- From:
Journal of China Pharmaceutical University
2022;53(3):264-272
- CountryChina
- Language:Chinese
-
Abstract:
With the development of biomimetic technology, more and more in vitro models are used to simulate human physiological and pathological processes.These in vitro models can solve some scientific problems, such as studying drug effects in real-timely and visually.As an in vitro model, organ-on-a-chip provides novel means and methods for basic and applied science.The vascularized organ-on-a-chip, as a special kind of organ-on-a-chip, can better simulate the structure and function of human blood vessels.In this review, we summarized the structure and function of different vascularized organ-on-a-chip, analyzed the application of vascularized organ-on-a-chip in simulating physiological and pathological processes, and discussed the advantages and problems to be solved of vascularized organ-on-a-chip as a new in vitro model.Finally, the application of vascularized organ-on-a-chip is proposed.
